Hydrophilic Realgar Nanocrystals Prolong the Survival of Refractory Acute Myeloid Leukemia Mice Through Inducing Multi-Lineage Differentiation and Apoptosis.
Tao WangXue ZhangMengfan JiaAiyun YangJian LiuTao WenJie MengHai-Yan XuPublished in: International journal of nanomedicine (2022)
induced effective and multiple-lineage differentiation and apoptosis of AML cells in the refractory AML mouse model and cell line, suggesting that it holds promising potential as a novel inductive agent in differentiation therapy of AML.
Keyphrases
- acute myeloid leukemia
- cell cycle arrest
- endoplasmic reticulum stress
- allogeneic hematopoietic stem cell transplantation
- induced apoptosis
- cell death
- mouse model
- oxidative stress
- pi k akt
- single cell
- high glucose
- type diabetes
- room temperature
- endothelial cells
- stem cells
- risk assessment
- high resolution
- cell therapy