Lack of Acute Agomelatine Effect in a Model of Social Anxiety in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial.
Rafael Guimarães Dos SantosIsabella C da Silva DiasAntonio W ZuardiRegina H C QueirozFrancisco S GuimarãesJaime E C HallakJosé Alexandre S CrippaPublished in: Journal of clinical psychopharmacology (2024)
Confirming previous results, a serotonin selective reuptake inhibitor, citalopram, caused an anxiogenic effect in the SPST only in females. Acute administration of a low dose of agomelatine failed to modify the behavioral and physiological changes caused by this test. Future studies using higher doses and repeated administration should investigate if agomelatine behavioral and physiological effects could be detected in human experimental anxiety models.