Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts.
Kristi S AnsethCierra J WalkerJoseph C GrimMegan E SchroederDilara BatanBrandon J VogtAndrea Gonzalez RodriguezJessica A SchwisowKaren S MoultonRobert M WeissDonald D HeistadLeslie A LeinwandLivia S A PassosPublished in: Circulation (2022)
Together, in vivo and in vitro results confirm sex dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent aortic valve stenosis progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of aortic valve stenosis and to help guide sex-based precision therapies.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic stenosis
- aortic valve replacement
- genome wide
- transforming growth factor
- copy number
- bioinformatics analysis
- genome wide identification
- heart failure
- pulmonary fibrosis
- dna methylation
- epithelial mesenchymal transition
- ejection fraction
- mitral valve
- atrial fibrillation