Brain metabolic correlates of apathy in amyotrophic lateral sclerosis: An 18F-FDG-positron emission tomography stud.
Antonio CanosaVeria VacchianoFabrizio D'OvidioAndrea CalvoCristina MogliaUmberto ManeraRosario VastaRocco LiguoriVincenzo ArenaMaurizio GrassanoFrancesca PalumboLaura PeottaBarbara IazzolinoMarco PaganiAdriano ChioPublished in: European journal of neurology (2020)
No studies on brain 18 F-2-fluoro-2-deoxy-D-glucose positron emission tomography correlates of apathy have been performed in ALS. We found that FrSBe "after" apathy subscore correlated with metabolic changes in brain regions known as neuroanatomical correlates of apathy. Furthermore, our findings support the relevance of the gap between premorbid and morbid conditions to detect behavioural changes due to the neurodegenerative process underlying ALS.