Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus.

A JeppssonÅ SandeliusA ZettergrenS KernI SkoogK BlennowH ZetterbergC WikkelsøP HellströmMats Tullberg

Published in: Fluids and barriers of the CNS (2023)

Plasma NFL is increased in iNPH patients and concentrations correlate with CSF NFL implying that plasma NFL can be used to assess evidence of axonal degeneration in iNPH. This finding opens a window for plasma samples to be used in future studies of other biomarkers in iNPH. NFL is probably not a very useful marker of symptomatology or for prediction of outcome in iNPH.

Keyphrases

cerebrospinal fluid
end stage renal disease
spinal cord injury
newly diagnosed
subarachnoid hemorrhage
peritoneal dialysis
small molecule
brain injury
patient reported outcomes
amino acid