A Bioinformatics Investigation into the Pharmacological Mechanisms of Sodium-Glucose Co-transporter 2 Inhibitors in Diabetes Mellitus and Heart Failure Based on Network Pharmacology.
Ziling MaiHuanqiang LiGuanzhong ChenEnzhao ChenLiwei LiuZhubin LunWenguang LaiChunyun ZhouSijia YuJin LiuShiqun ChenJiyan ChenYong LiuPublished in: Cardiovascular drugs and therapy (2021)
Our study elucidated the possible mechanisms of SGLT2 inhibitors from a systemic and holistic perspective based on pharmacological networks. The key targets and pathways will provide new insights for further research on the pharmacological mechanism of SGLT2 inhibitors in the treatment of DM with HF.