Increased Circulating Chemokines and Macrophage Recruitment in Growing Vestibular Schwannomas.

Cathal John HannanDaniel LewisClaire O'LearyMueez WaqarDavid BroughKevin N CouperDouglas P DyerAndy VailCalvin HealJoshua MacarthurChristopher CooperCharlotte Hammerbeck-WardD Gareth EvansScott A RutherfordSimon K LloydSimon Richard Mackenzie FreemanDavid John CoopeAndrew T KingOmar Nathan Pathmanaban

Published in: Neurosurgery (2022)

There is a strong positive correlation between TAM infiltration and volumetric growth of VS, and this relationship is independent of tumor size. There is a colinear relationship between TAM infiltration and tumor vascularity, implying that inflammation and angiogenesis are interlinked in VS. Chemokines known to induce monocyte chemotaxis are found in higher concentrations in patients with growing VS, suggestive of a potential pathophysiological mechanism.

Keyphrases

endothelial cells
oxidative stress
adipose tissue
dendritic cells
vascular endothelial growth factor
peripheral blood