Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
Machteld SillenStephen D WeeksXiaohua ZhouAndrey A KomissarovGalina FlorovaSteven IdellSergei V StrelkovPaul J DeclerckPublished in: Journal of thrombosis and haemostasis : JTH (2020)
These findings illuminate the molecular mechanisms of PAI-1 inhibition. Nb42 and Nb64 can be used as starting points to engineer further improved antibody-based PAI-1 inhibitors or guide the rational design of small molecule inhibitors to treat a wide range of PAI-1-related pathophysiological conditions.
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