Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer.

Sophia C Kamran Jochen K LennerzClaire A MargolisDavid R LiuBrendan ReardonStephanie A WankowiczEmily E Van SeventerAdam TracyJennifer Y WoScott L CarterHenning WillersRyan B CorcoranTheodore S HongEliezer M Van Allen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Overall, while CRT did not impact genomic profiles, CRT impacted the tumor immune microenvironment, particularly in resistant cases.

Keyphrases

rectal cancer
locally advanced
cardiac resynchronization therapy
stem cells
left ventricular
heart failure
copy number
squamous cell carcinoma
radiation therapy
network analysis
gene expression
lymph node
genome wide