Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling.

Lixia ZhangCameron L KirkwoodJiho SohnAshley LauMary Bayers-TheringSupinder Kour BaliSridhar RachalaJohn M MarzoMark J AndersFrank BeierKeith L Kirkwood

Published in: Arthritis research & therapy (2021)

These data suggest that MDSCs are reprogrammed in metabolic disease, with the potential to contribute towards OA progression and severity.

Keyphrases

induced apoptosis
knee osteoarthritis
cell cycle arrest
bone mineral density
electronic health record
big data
oxidative stress
machine learning
human health
body composition
bone regeneration
climate change