Current status of micro/nanomotors in drug delivery.
Gizem TezelSelin Seda TimurFiliz KuralayR Neslihan GürsoyKezban UlubayramLevent OnerHakan EroğluPublished in: Journal of drug targeting (2020)
Synthetic micro/nanomotors (MNMs) are novel, self-propelled nano or microscale devices that are widely used in drug transport, cell stimulation and isolation, bio-imaging, diagnostic and monitoring, sensing, photocatalysis and environmental remediation. Various preparation methods and propulsion mechanisms make MNMs "tailormade" nanosystems for the intended purpose or use. As the one of the newest members of nano carriers, MNMs open a new perspective especially for rapid drug transport and gene delivery. Although there exists limited number of in-vivo studies for drug delivery purposes, existence of in-vitro supportive data strongly encourages researchers to move on in this field and benefit from the manoeuvre capability of these novel systems. In this article, we reviewed the preparation and propulsion mechanisms of nanomotors in various fields with special attention to drug delivery systems.
Keyphrases
- drug delivery
- current status
- cancer therapy
- molecularly imprinted
- high resolution
- single cell
- drug release
- electronic health record
- working memory
- cell therapy
- minimally invasive
- adverse drug
- drug induced
- big data
- mesenchymal stem cells
- bone marrow
- stem cells
- climate change
- loop mediated isothermal amplification
- machine learning
- case control
- deep learning
- visible light