Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.
Zoë Rachael GoddardAndrew Michael BeekmanMarco M D CominettiMaria A O'ConnellIsabelle ChambrierMichael J CookMaría J MarínDavid A RussellMark SearceyPublished in: RSC medicinal chemistry (2020)
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.