Preload dependence in an animal model of mild heart failure with preserved ejection fraction (HFpEF).

Jens C B JacobsenIrene H SchubertKarin LarsenDijana TerzicLouise ThistedNobuhisa Nakamura

Published in: Acta physiologica (Oxford, England) (2024)

This animal model successfully developed mild HFpEF with a reduced pump function that was dependent on a high preload. A model of mild HFpEF may serve as a valuable tool for studying disease progression and interventions aimed at delaying or reversing symptom advancement, considering the slow development of HFpEF in patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
physical activity
peritoneal dialysis
prognostic factors
patient reported