Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits.

Yan ZhangJingyu XieSimin WenPeihua CaoWende XiaoJianwei ZhuShengfa LiZhiqiang WangHan CenZhaohua Zhu Changhai Ding Guangfeng Ruan

Published in: Annals of the rheumatic diseases (2023)

Through MR analysis, we have identified numerous plasma proteins associated with OA-related traits, shedding light on protein-mediated mechanisms and offering promising therapeutic targets for OA.

Keyphrases

knee osteoarthritis
genome wide
rheumatoid arthritis
magnetic resonance
gene expression
dna methylation
binding protein
amino acid