Login / Signup

Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp.

Wah Seng See-TooPeter ConveyDavid A PearceKok Gan Chan
Published in: Microbial cell factories (2018)
We demonstrated that AidP is effective in attenuating the pathogenicity of P. carotovorum, a plant pathogen that causes soft-rot disease. This anti-quorum sensing agent is an enzyme with low thermal stability that degrades the bacterial signalling molecules (AHLs) that are produced by many pathogens. Since the enzyme is most active below human body temperature (below 28 °C), and lose its activity drastically above 32 °C, the results of a pectinolytic inhibition assay using Chinese cabbage indicated the potential of this anti-quorum sensing agent to be safely applied in the field trials.
Keyphrases
  • endothelial cells
  • high throughput
  • induced pluripotent stem cells
  • gram negative
  • biofilm formation
  • pseudomonas aeruginosa
  • staphylococcus aureus
  • single cell