Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice.

Yinan YangChangwei WeiJinhu LiuDanxu MaChao XiongDandan LinAn-Shi Wu

Published in: The Journal of international medical research (2021)

These results indicated that atorvastatin improves several hippocampal functions and alleviates inflammation in PND mice after surgery, probably through a PPARγ-involved signaling pathway.

Keyphrases

signaling pathway
high fat diet induced
pi k akt
oxidative stress
epithelial mesenchymal transition
insulin resistance
induced apoptosis
wild type
type diabetes
mouse model
blood brain barrier
binding protein
cerebral ischemia