Comparative Research: Regulatory Mechanisms of Ribosomal Gene Transcription in Saccharomyces cerevisiae and Schizosaccharomyces pombe .
Hayato HiraiKunihiro OhtaPublished in: Biomolecules (2023)
Restricting ribosome biosynthesis and assembly in response to nutrient starvation is a universal phenomenon that enables cells to survive with limited intracellular resources. When cells experience starvation, nutrient signaling pathways, such as the target of rapamycin (TOR) and protein kinase A (PKA), become quiescent, leading to several transcription factors and histone modification enzymes cooperatively and rapidly repressing ribosomal genes. Fission yeast has factors for heterochromatin formation similar to mammalian cells, such as H3K9 methyltransferase and HP1 protein, which are absent in budding yeast. However, limited studies on heterochromatinization in ribosomal genes have been conducted on fission yeast. Herein, we shed light on and compare the regulatory mechanisms of ribosomal gene transcription in two species with the latest insights.
Keyphrases
- saccharomyces cerevisiae
- transcription factor
- genome wide identification
- induced apoptosis
- genome wide
- cell cycle arrest
- signaling pathway
- dna methylation
- cell wall
- endoplasmic reticulum stress
- protein kinase
- copy number
- pi k akt
- gene expression
- dna binding
- cell death
- reactive oxygen species
- epithelial mesenchymal transition
- case control
- binding protein