Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway.

Xin WuJia-Ming LiuHong-Hai SongQi-Kun YangHui YingWei-Lai TongYang ZhouZhi Li Liu

Published in: Cancer cell international (2020)

Our results suggest that silencing of Aurora-B stimulate autophagy via decreasing mTOR/ULK1 and result in inhibiting OS metastasis. Targeted Aurora-B/mTOR/ULK1 pathway may be a promising treatment strategy for OS patients.

Keyphrases

signaling pathway
end stage renal disease
cell proliferation
cell death
endoplasmic reticulum stress
ejection fraction
newly diagnosed
oxidative stress
chronic kidney disease
peritoneal dialysis
prognostic factors
cancer therapy
drug delivery