Intramyometrial and intravenous oxytocin compared to intravenous carbetocin for prevention of postpartum hemorrhage in elective cesarean section-A quasi-randomized controlled phase IV non-inferiority interventional trial.

Romana BrunLea MeierElisabeth KapfhammerRoland ZimmermannNicole Ochsenbein-KölbleChristian Haslinger

Published in: Acta obstetricia et gynecologica Scandinavica (2024)

Combined (IM/IV) oxytocin is not non-inferior to carbetocin regarding severe postpartum blood loss defined as postpartum Hb decrease ≥30 g/L in elective cesarean sections. We recommend carbetocin for use in clinical practice for elective cesarean sections.

Keyphrases

patients undergoing
phase iii
clinical practice
phase ii
high dose
open label
double blind
clinical trial
placebo controlled