Defining optimal sulbactam regimens for treatment of Acinetobacter baumannii pneumonia and impact of blaOXA-23 on efficacy.
Yasmeen AbouelhassanDavid P NicolauKamilia AbdelraoufPublished in: The Journal of antimicrobial chemotherapy (2024)
A sulbactam high-dose prolonged-infusion regimen provides comparable activity to the standard dose against isolates currently considered sulbactam susceptible. However, the activity against isolates with intermediate and resistant susceptibility could be predicted by the detection of blaOXA-23. Enhancing detection capabilities of common diagnostic modalities to include OXA-23 can improve patient outcome.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- drug resistant
- pseudomonas aeruginosa
- high dose
- low dose
- loop mediated isothermal amplification
- real time pcr
- label free
- genetic diversity
- case report
- cystic fibrosis
- stem cell transplantation
- klebsiella pneumoniae
- escherichia coli
- acute respiratory distress syndrome
- respiratory failure
- mechanical ventilation
- sensitive detection