Dynamic ultrasound molecular-targeted imaging of senescence in evaluation of lapatinib resistance in HER2-positive breast cancer.
Xiaoyu ChenYing LiZhiwei ZhouYanqiu ZhangLuchen ChangXiujun GaoQing LiHao LuoKenneth D WestoverJialin ZhuXi WeiPublished in: Cancer medicine (2023)
Our data demonstrate that cellular senescence-based ultrasound-targeted imaging can identify reversible senescence and evaluate LAP resistance effectively in HER2+ breast cancer cells, which has the potential to improve cancer treatment outcomes by altering therapeutic strategies ahead of aggressive recurrences.
Keyphrases
- positive breast cancer
- dna damage
- endothelial cells
- high resolution
- breast cancer cells
- magnetic resonance imaging
- stress induced
- cancer therapy
- papillary thyroid
- electronic health record
- contrast enhanced ultrasound
- squamous cell carcinoma
- squamous cell
- mass spectrometry
- fluorescence imaging
- risk assessment
- young adults
- lymph node metastasis
- artificial intelligence
- childhood cancer