A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study.

Hiroshi OnishiChihiro UdagawaMichiaki KuboSeigo NakamuraSadako Akashi-TanakaTakashi KuwayamaChie WatanabeTomoko TakamaruHiroyuki TakeiTakashi IshikawaKana MiyaharaHiroshi MatsumotoYoshie HasegawaYukihide MomozawaSiew-Kee LowGoro KutomiHiroaki ShimaFukino SatomiMinoru OkazakiHisamitsu ZahaMai OnomuraAyami MatsukataYasuaki SagaraShinichi BabaAkimitsu YamadaKazuhiro ShimadaDaisuke ShimizuKoichiro TsugawaArata ShimoMikael HartmanChing-Wan ChanSoo Chin LeeItaru EndoHitoshi Zembutsu

Published in: PloS one (2018)

We identified three novel loci, which could be associated with clinical response to tamoxifen. These findings provide new insights into personalized hormonal therapy for the patients with breast cancer.

Keyphrases

genome wide association study
genome wide
breast cancer cells
estrogen receptor
positive breast cancer
dna methylation
polycystic ovary syndrome
gene expression
type diabetes
skeletal muscle