Maturation of amyloid β fibrils alters their molecular stability.
Stefan BeckerKarin GillerDaniel SiemeNasrollah Rezaei-GhalehPublished in: Physical chemistry chemical physics : PCCP (2023)
Little is known about how maturation of Alzheimer's disease-related amyloid β (Aβ) fibrils alters their stability and potentially influences their spreading in the brain. Using high-pressure NMR, we show that progression from early to late Aβ40 aggregates enhances the kinetic stability, while ageing during weeks to months enhances their thermodynamic stability.