Quantifying the heterogeneity of cognitive functioning in Alzheimer's disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil.

Stephen Z Levine Yair Goldberg Kazufumi Yoshida Myrto T Samara Andrea Cipriani Takeshi Iwatsubo Stefan Leucht Toshiaki A Furawaka

Published in: European psychiatry : the journal of the Association of European Psychiatrists (2021)

Our results inform clinicians regarding the extent of heterogeneity in cognitive functioning during treatment and contribute to trial design considerations.

Keyphrases

single cell
phase iii
study protocol
palliative care
electronic health record
cognitive decline
phase ii
combination therapy
machine learning
open label
mild cognitive impairment
artificial intelligence