Quantifying the heterogeneity of cognitive functioning in Alzheimer's disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil.
Stephen Z LevineYair GoldbergKazufumi YoshidaMyrto T SamaraAndrea CiprianiTakeshi IwatsuboStefan LeuchtToshiaki A FurawakaPublished in: European psychiatry : the journal of the Association of European Psychiatrists (2021)
Our results inform clinicians regarding the extent of heterogeneity in cognitive functioning during treatment and contribute to trial design considerations.