Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.
Kea MartinRatiba TouilGrozdan CvijeticLaura IsraelYeter KolbSophie SarretStéphanie ValeauxElena Degl'InnocentiThomas Le MeurNadja CaesarMaureen BardetChristian BeerliHans-Guenter ZerwesJiri KovarikKaren BeltzAchim SchlapbachJean QuancardCatherine H RégnierMarc BigaudTobias JuntGrazyna WieczorekIsabelle IsnardiAmanda Littlewood-EvansFrédéric BornancinThomas CalzasciaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our findings indicate a specific contribution of MALT-1 protease activity to FcγR-mediated events and suggest that MALT-1 protease inhibitors have therapeutic potential in a subset of FcγR-driven inflammatory disorders.