Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Li LuHailin WangXuan LiuLiping TanXiaoyue QiaoJiali NiYang SunJun LiangYayi HouHuan DouPublished in: Journal of neuroinflammation (2021)
These data indicate that microglial PKM2 have potential to become a novel therapeutic target for treating lupus encephalopathy.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- neuropathic pain
- systemic lupus erythematosus
- electronic health record
- early onset
- disease activity
- big data
- mild cognitive impairment
- protein kinase
- tyrosine kinase
- spinal cord
- prefrontal cortex
- spinal cord injury
- machine learning
- climate change
- deep learning