Is CD25 blockade optimal in kidney transplant patients treated with basiliximab? A target-mediated drug disposition model.

Olivier Le TillyPhilippe GataultChristophe BaronTheodora Bejan-AngoulvantMatthias BüchlerGilles PaintaudDavid Ternant

Published in: British journal of clinical pharmacology (2022)

This analysis allows the first description of the target-mediated nonlinear elimination of basiliximab. Our results suggest that cyclosporine cotreatment is associated with decreased target level and that an optimized dosing regimen may improve basiliximab effects.

Keyphrases

emergency department
adverse drug
data analysis