High-throughput micro-CT analysis identifies sex-dependent biomarkers of erosive arthritis in TNF-Tg mice and differential response to anti-TNF therapy.
H Mark KenneyKiana L ChenLindsay SchnurJeffrey I FoxRonald W WoodLianping XingChristopher T RitchlinHomaira RahimiEdward M SchwarzHani A AwadPublished in: PloS one (2024)
We demonstrated that sexually dimorphic changes in arthritic hindpaws of TNF-Tg mice are bone-specific, where the cuboid serves as a reliable early biomarker of erosive arthritis in female mice. Adoption of automated segmentation approaches in pre-clinical or clinical models has potential to translate quantitative biomarkers to monitor bone erosions in disease and evaluate therapeutic efficacy.
Keyphrases
- rheumatoid arthritis
- high throughput
- high fat diet induced
- deep learning
- bone mineral density
- computed tomography
- stem cells
- machine learning
- high resolution
- type diabetes
- wild type
- mass spectrometry
- genome wide
- bone loss
- climate change
- dna methylation
- electronic health record
- skeletal muscle
- risk assessment
- body composition
- dual energy
- positron emission tomography
- data analysis
- cell therapy