Single-cell transcriptomics reveals a low CD8 + T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma.

Yu-Lu PengLong-Bin XiongZhao-Hui ZhouKang NingZhen LiZe-Shen WuMin-Hua DengWen-Su WeiNing WangXiang-Peng ZouZhi-Song HeJi-Wei HuangJunghang LuoJian-Ye LiuNan JiaYun CaoHui HanSheng-Jie GuoPei DongChun-Ping YuFang-Jian ZhouZhi-Ling Zhang

Published in: Journal for immunotherapy of cancer (2022)

T cells via Gal1. Targeting Gal1 combined with anti-PD1 showed promising efficacy in treating RCC.

Keyphrases

renal cell carcinoma
single cell
rna seq
high throughput
cancer therapy
extracellular matrix
drug delivery