Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes.

Hironobu SasakiYoshifumi SaishoJun InaishiYuusuke WatanabeTami TsuchiyaMasayoshi MakioMidori SatoMasaru NishikawaMinoru KitagoTaketo YamadaHiroshi Itoh

Published in: Diabetologia (2021)

Both beta cell size and number were reduced in participants with type 2 diabetes, with the relative reduction in beta cell number being greater. Decrease in beta cell number appears to be a major contributor to reduced BCM in type 2 diabetes.

Keyphrases

type diabetes
single cell
cell therapy
cardiovascular disease
metabolic syndrome