Population Pharmacokinetic Analysis and Dosing Optimization Based on Unbound Daptomycin Concentration and Cystatin C in Nonobese Elderly Patients with Hypoalbuminemia and Chronic Kidney Disease.

Masaru SamuraKeisuke TakadaRisako YamamotoHayato ItoFumio NagumoMasaki UchidaTakenori KurataSakura KoshiokaYuki EnokiKazuaki TaguchiRyuji HigashitaNorifumi KunikaKoji TanikawaKazuaki Matsumoto

Published in: Pharmaceutical research (2021)

These results suggest that establishing the dose using total concentrations may result in under- or overestimation caused by alterations in fu. The optimal dose for nonobese elderly patients with hypoalbuminemia and CKD depends on eGFRcys and age, and a standard dose may be insufficient for some patients.

Keyphrases

chronic kidney disease
end stage renal disease
peritoneal dialysis
middle aged
ejection fraction
newly diagnosed
prognostic factors
patient reported