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A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.

Jian-Guo LiJin ChiuMercy RamanjuluBenjamin E BlassDomenico Pratico
Published in: Molecular neurodegeneration (2020)
Our study demonstrates that the enhancement of retromer function by pharmacological chaperones is a potentially novel and viable therapy against AD.
Keyphrases
  • mouse model
  • heat shock
  • working memory
  • stem cells
  • heat shock protein
  • cerebrospinal fluid
  • oxidative stress
  • endoplasmic reticulum
  • cell therapy
  • smoking cessation