A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Jian-Guo LiJin ChiuMercy RamanjuluBenjamin E BlassDomenico PraticoPublished in: Molecular neurodegeneration (2020)
Our study demonstrates that the enhancement of retromer function by pharmacological chaperones is a potentially novel and viable therapy against AD.