The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices.

Dimakatso Alice SenthebaneTina JonkerArielle RoweNicholas Ekow ThomfordDaniella MunroCollet DandaraAmbroise WonkamDhirendra GovenderBridget CalderNelson Cruz Soares Jonathan Michael Blackburn Mohamed Iqbal Parker Kevin Dzobo

Published in: International journal of molecular sciences (2018)

Our study shows that ECM proteins play a key role in the response of cancer cells to chemotherapy and suggest that targeting ECM proteins can be an effective therapeutic strategy against chemoresistant tumors.

Keyphrases

extracellular matrix
cancer therapy
locally advanced
radiation therapy
drug delivery