Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction.
Kristen D OnosPeter B LinRavi S PandyScott A PersohnCharles P BurtonEthan W MinerKierra EldridgeJonathan Nyandu KanyindaKate E FoleyGregory W CarterGareth R HowellPaul R TerritoPublished in: bioRxiv : the preprint server for biology (2024)
This work highlights APOEe4 status in AD progression manifest as neurovascular uncoupling driven by immunological activation, and may serve as an early diagnostic biomarker.