RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells.

Carla BosiaFrancesco SgròLaura ContiCarlo BaldassiDavide BrusaFederica CavalloFerdinando Di CuntoEmilia TurcoAndrea PagnaniRiccardo Zecchina

Published in: Genome biology (2017)

Our results are summarized in a phase diagram for miRNA-mediated cross-regulation that links experimentally measured quantities and effective model parameters. This phase diagram can be applied to in vivo studies of RNAs that are in competition for miRNA binding.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
cell proliferation
dna binding
neural network