Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids.
Andrew J BorelandAlessandro C StillitanoHsin-Ching LinYara AbboRonald P HartPeng JiangZhiping P PangArnold B RabsonPublished in: bioRxiv : the preprint server for biology (2023)
HIV-1 productively infects iPSC-derived microglia and triggers inflammatory activation.HIV-1 infection of microglia results in sustained type I interferon signaling.Microglia infected by HIV-1 incorporate into sliced neocortical organoids with persistent type I interferon signaling and disease risk gene expression.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- induced pluripotent stem cells
- hepatitis c virus
- hiv positive
- inflammatory response
- gene expression
- hiv aids
- neuropathic pain
- dendritic cells
- hiv testing
- endothelial cells
- dna methylation
- men who have sex with men
- subarachnoid hemorrhage
- spinal cord
- spinal cord injury
- oxidative stress
- south africa
- blood brain barrier