Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations.
Syuzo KanekoKen TakasawaKen AsadaKouya ShiraishiNoriko IkawaHidenori MachinoNorio ShinkaiMaiko MatsudaMari MasudaShungo AdachiSatoshi TakahashiKazuma KobayashiNobuji KounoAmina BolatkanMasaaki KomatsuMasayoshi YamadaMototaka MiyakeHirokazu WatanabeAkiko TateishiTakaaki MizunoYu OkuboMasami MukaiTatsuya YoshidaYukihiro YoshidaHidehito HorinouchiShun-Ichi WatanabeYuichiro OheYasushi YatabeVassiliki SalouraTakashi KohnoRyuji HamamotoPublished in: Molecular cancer (2024)
Our findings suggest that aberrant gene expression linked to structural polymorphisms can significantly impact personalized cancer treatment by facilitating the identification of driver mutations and prognostic factors, contributing to a more comprehensive understanding of LUAD pathogenesis.