Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing.

Manuel IbarraRyan CombsZachary L TaylorLaura B RamseyTorben MikkelsenRandal K BuddingtonJesper HeldrupJason N BarretoMartin GuscottJennifer LoweCharles HurmizSuresh MaradaScott C HowardPaula S Schaiquevich

Published in: British journal of clinical pharmacology (2022)

We developed a population pharmacometric model that considers weight, albumin and time-dependent creatinine that can be used to guide supportive care in adult patients with delayed HDMTX elimination.

Keyphrases

papillary thyroid
healthcare
palliative care
squamous cell
body mass index
physical activity
quality improvement
weight loss
weight gain
uric acid
affordable care act
childhood cancer
body weight
metabolic syndrome
young adults
chronic pain
health insurance