Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature.
Josephina P M VrouwePauline M L HennusNeveen A T HamdySusanne OsantoPeter-Paul M WillemsePublished in: BJUI compass (2022)
TGCT survivors are at risk of developing osteoporosis and sustaining fragility fractures. Chemotherapy, pituitary-gonadal axis dysfunction and ageing are key risk factors, although available data are scarce. With increasing survival of TGCT patients, a clear unmet need has been identified to systematically evaluate and monitor skeletal health in larger numbers of survivors in order to develop best clinical practice guidelines to manage the insidious but potentially preventable and treatable skeletal complications of TGCT.
Keyphrases
- germ cell
- risk factors
- young adults
- end stage renal disease
- postmenopausal women
- bone mineral density
- healthcare
- ejection fraction
- chronic kidney disease
- public health
- peritoneal dialysis
- prognostic factors
- mental health
- oxidative stress
- emergency department
- squamous cell carcinoma
- electronic health record
- radiation therapy
- locally advanced
- patient reported outcomes
- free survival
- deep learning
- rectal cancer
- health promotion
- drug induced
- hip fracture