Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection.
Leila RoncerayOussama AblaShlomit Barzilai-BirenboimSimon BomkenAlan Ks ChiangJanez JazbecEdita KabickovaJelena LazicAuke BeishuizenKarin MellgrenFumiko TanakaMarta PillonChristine DevalckMarina GouttenoireOlga MakarovaBirgit BurkhardtAndishe Attarbaschinull nullPublished in: Pediatric blood & cancer (2017)
Data on management of pediatric marginal zone lymphoma (MZL) are scarce. This retrospective study assessed characteristics and outcome in 66 patients who were <18 years old. Forty-four (67%) had an extranodal MZL (EMZL), 21 (32%) a nodal MZL (NMZL), and one patient a splenic MZL. Thirty-three patients (50%) received a variable combination of adjuvant chemotherapy/immunotherapy/radiotherapy, while the remainder, including 20 of 21 with NMZL, entered an active observation period. Overall survival was excellent (98 ± 2%), although 11 patients relapsed (17%; NMZL, n = 1; EMZL, n = 10), seven after any therapy and four after complete resection only. In conclusion, outcome of NZML, in particular, seems to be excellent after (in)complete resection and observation only.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- diffuse large b cell lymphoma
- prognostic factors
- early stage
- acute myeloid leukemia
- stem cells
- radiation therapy
- acute lymphoblastic leukemia
- machine learning
- locally advanced
- multiple myeloma
- young adults
- case report
- radiation induced
- neoadjuvant chemotherapy
- electronic health record
- deep learning
- mesenchymal stem cells
- cell therapy
- patient reported
- free survival