New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696.
Olesya I ZhuravlevaGalina K OleinikovaAlexandr S AntonovNatalia N KirichukDmitry N PelageevAnton B RasinAlexander S MenshovRoman S PopovNatalya Yu KimEkaterina A ChingizovaArtur R ChingizovOlga O VolchkovaGunhild von AmsbergSergey A DyshlovoyEkaterina A YurchenkoIrina V GuzhovaAnton Nikolaevich YurchenkoPublished in: Journal of fungi (Basel, Switzerland) (2022)
Six new polyketides acrucipentyns A-F ( 1 - 6 ) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.
Keyphrases
- staphylococcus aureus
- biofilm formation
- data analysis
- wound healing
- methicillin resistant staphylococcus aureus
- endothelial cells
- pseudomonas aeruginosa
- candida albicans
- molecular docking
- drinking water
- soft tissue
- induced pluripotent stem cells
- high resolution
- silver nanoparticles
- molecular dynamics simulations
- cystic fibrosis