Early Outpatient Treatment for Covid-19 with Convalescent Plasma.
David J SullivanKelly A GeboShmuel ShohamEvan M BlochBryan LauAarthi G ShenoyGiselle S MosnaimThomas J GniadekYuriko FukutaBela PatelSonya L HeathAdam C LevineBarry R MeisenbergEmily S SpivakShweta AnjanMoises A HuamanJanis E BlairJudith S CurrierJames H PaxtonJonathan M GerberJoann R PetriniPatrick B BroderickWilliam RauschMarie-Elena CordiscoJean HammelBenjamin GreenblattValerie C CluzetDaniel CruserKevin OeiMatthew AbinanteLaura L HammittCatherine G SutcliffeDonald N ForthalMartin S ZandEdward R CachayJay S RavalSeble G KassayeE Colin FosterMichael RothChristi E MarshallAnusha YaravaKaren LaneNichol A McBeeAmy L GawadNicky KarlenAtika SinghDaniel E FordDouglas A JabsLawrence J AppelDavid M ShadeStephan EhrhardtSheriza N BakshOliver LaeyendeckerAndrew S PekoszSabra L KleinArturo CasadevallAaron A R TobianDaniel F HanleyPublished in: The New England journal of medicine (2022)
In participants with Covid-19, most of whom were unvaccinated, the administration of convalescent plasma within 9 days after the onset of symptoms reduced the risk of disease progression leading to hospitalization. (Funded by the Department of Defense and others; CSSC-004 ClinicalTrials.gov number, NCT04373460.).