The effect of splenectomy on the levels of PCV-13-induced memory B- and T cells.
Umut GaziDjursun Karasartovaİbrahim Tayfun ŞahinerAyse Semra GureserOzgur TosunMehmet Kursat DericiMete DolapciAysegul Taylan OzkanPublished in: International journal of clinical practice (2018)
Our results suggest that spleen is important, but not essential, for survival and/or generation of memory IgG B cells. In contrast, it seems to be indispensable for PCV-13-specific memory TH 1-cell levels. Studies enhancing the levels of vaccine-induced memory cells and further enlightening the immune responses in asplenic individuals are required to develop more effective vaccination strategies against OPSI.