MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.
Pierre-Antoine JugeJoyce S LeeEsther EbsteinHiroshi FurukawaEvgenia DobrinskikhSteven GazalCaroline KannengiesserSébastien OttavianiShomi OkaShigeto TohmaNaoyuki TsuchiyaJorge Rojas-SerranoMontserrat I González-PérezMayra MejíaIvette Buendía-RoldánRamcés Falfan-ValenciaEnrique Ambrocio-OrtizEffrosyni ManaliSpyros A PapirisTheofanis KarageorgasDimitrios BoumpasKatarina AntoniouColine H M van MoorselJoanne van der VisYaël A de ManJan C GruttersYaping WangRaphaël BorieLidwine Wemeau-StervinouBenoît WallaertRené-Marc FlipoHilario NunesDominique ValeyreNathalie Saidenberg-Kermanac'hMarie-Christophe BoissierSylvain Marchand-AdamAline FrazierPascal RichetteYannick AllanoreJean SibiliaClaire DromerChristophe RichezThierry SchaeverbekeHuguette LiotéGabriel ThabutNadia NathanSerge AmselemMartin SoubrierVincent CottinAnnick ClémentKevin DeaneAvram D WaltsTasha FingerlinAryeh FischerJay H RyuEric L MattesonTimothy B NiewoldDeborah AssayagAndrew GrossPaul WoltersMarvin I SchwarzMichael HolersJoshua J SolomonTracy DoyleIvan O RosasCornelis BlauwendraatMike A NallsMarie-Pierre DebrayCatherine BoileauBruno CrestaniDavid A SchwartzPhilippe DieudéPublished in: The New England journal of medicine (2018)
We found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging. (Funded by Société Française de Rhumatologie and others.).