Acute Promyelocytic Leukemia with t(2;3): An Unusual Additional Chromosomal Abnormality.

Smeeta GajendraAnil Kumar YadavManorama Bhargava

Published in: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion (2021)

Acute promyelocytic leukemia is a distinct subset of acute myeloid leukemia with characteristic clinical, morphological and genetic features. The gene product PML-RAR alpha resulting from reciprocal t(15;17) translocation, plays a pivotal role in the pathogenesis of acute promyelocytic leukemia and classified as favorable cytogenetic features. We are describing an unusual additional chromosomal abnormality t(2;3) in APL patient.

Keyphrases

acute myeloid leukemia
liver failure
respiratory failure
copy number
bone marrow
aortic dissection
drug induced
genome wide
hepatitis b virus
case report
gene expression
dna methylation
extracorporeal membrane oxygenation
genome wide identification