Multifactorial White Matter Damage in the Acute Phase and Pre-Existing Conditions May Drive Cognitive Dysfunction after SARS-CoV-2 Infection: Neuropathology-Based Evidence.
Ellen GelpíSigrid KlotzMiriam BeyerleSven WischnewskiVerena HarterHarald KirschnerKatharina StolzChristoph ReisingerElisabeth Lindeck-PozzaAlexander ZoufalyMarlene LeoniGregor GorkiewiczMartin ZachariasChristine HaberlerJohannes HainfellnerAdelheid WöhrerSimon HametnerThomas Roetzer-PejrimovskyTill VoigtländerGerda RickenVerena EndmayrCarmen HaiderJudith LudwigAndrea PoltGloria WilkSusanne SchmidIrene ErbenAnita NguyenSusanna LangIngrid Simonitsch-KluppChristoph KornauthMaja NackenhorstJohannes KlägerRenate KainAndreas ChottRichard WasickyRobert KrauseGuenter WeissJudith Löffler-RagThomas BergerPatrizia MoserAfshin SoleimanMartin AsslaberRoland SedivyNikolaus KluppMartin KlimpfingerDaniele RisserHerbert BudkaLucas SchirmerAnne-Katrin PröbstelRomana HöftbergerPublished in: Viruses (2023)
Our results support some previous neuropathological findings of apparently multifactorial and most likely indirect brain damage in the context of SARS-CoV-2 infection rather than virus-specific damage, and they are in line with the recent experimental data on SARS-CoV-2-related diffuse white matter damage, microglial activation, and cytokine release.