The S1PR2-CCL2-BDNF-TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia.
Yaiza M ArenasTiziano BalzanoGergana IvaylovaMarta LlansolaVicente FelipoPublished in: Neuropathology and applied neurobiology (2022)
Enhanced S1PR2-CCL2-BDNF-TrkB pathway activation mediates neuroinflammation and incoordination in hyperammonaemia. The data raise a promising therapy for patients with hepatic encephalopathy using compounds targeting this pathway.