Microstructure of the cerebellum and its afferent pathways underpins dystonia in myoclonus dystonia.
Clément TarranoGiuseppe ZitoCécile GalléaCécile DelormeEavan M McGovernCyril Atkinson-ClementVanessa BrochardStéphane ThoboisChristine TranchantDavid GrabliBertrand DegosJean Christophe CorvolJean-Michel PedespanPierre KrystkowiakJean-Luc HouetoAdrian DegardinLuc DefebvreMélanie DidierRomain ValabrègueEmmanuelle ApartisMarie VidailhetEmmanuel RozeYulia WorbePublished in: European journal of neurology (2024)
In MYC/DYT-SGCE, we found microstructural reorganization of the motor cerebellum. Structural change in the cerebellar afferent pathways that relay inputs from the spinal cord and the cerebral cortex were specifically associated with the severity of dystonia.