Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.

Heiko KrothFelix OdenJerome MoletteHanno SchiefersteinFrancesca CapotostiAndre MuellerMathias BerndtHeribert Schmitt-WillichVincent DarmencyEmanuele GabellieriCédric BoudouTanja JuergensYvan VariscoEfthymia VokaliDavid T HickmanGilles TamagnanAndrea PfeiferLudger DinkelborgAndreas MuhsAndrew W Stephens

Published in: European journal of nuclear medicine and molecular imaging (2019)

Therefore, [18F]PI-2620 was selected for clinical validation.

Keyphrases

positron emission tomography
cerebrospinal fluid
pet imaging
small molecule
computed tomography
pet ct
cognitive decline
high throughput
cell therapy
stem cells
bone marrow