Acacetin inhibits activation of microglia to improve neuroinflammation after subarachnoid hemorrhage through the PERK signaling pathway mediated autophagy.
Ying LiuJianhua TangYiwei HouLu LiWenna LiLing YuXue WangChangbai SuiPublished in: Human & experimental toxicology (2024)
Acacetin may alleviate neuroinflammation and neuronal damage through PERK pathway, thus having the protective effect on EBI after SAH.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- endoplasmic reticulum stress
- signaling pathway
- induced apoptosis
- brain injury
- oxidative stress
- endoplasmic reticulum
- pi k akt
- blood brain barrier
- inflammatory response
- cell death
- epithelial mesenchymal transition
- lipopolysaccharide induced
- traumatic brain injury
- neuropathic pain
- cognitive impairment
- cell proliferation